abstract：:Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulatio...

journal_title：International journal of molecular sciences

authors： Yang G,Shi R,Zhang Q

更新日期：2020-10-31 00:00:00

abstract：:Dysbiosis, an imbalance of intestinal flora, can cause serious conditions such as obesity, cancer, and psychoneurological disorders. One cause of dysbiosis is inflammation. Ulcerative enteritis is a side effect of non-steroidal anti-inflammatory drugs (NSAIDs). To counteract this side effect, we proposed the concurren...

journal_title：International journal of molecular sciences

authors： Kawashima R,Tamaki S,Kawakami F,Maekawa T,Ichikawa T

更新日期：2020-10-31 00:00:00

abstract：:Idiopathic osteoporosis and nephrolithiasis are formidable health problems showing a progressive increase in their incidence and prevalence in the last decades. These temporal trends were observed in both pediatric and adult populations worldwide. Epidemiological and experimental studies indicate that both disorders s...

journal_title：International journal of molecular sciences

authors： Rendina D,De Filippo G,Iannuzzo G,Abate V,Strazzullo P,Falchetti A

更新日期：2020-10-31 00:00:00

abstract：:For the last decade, porcine epidemic diarrhea virus (PEDV) variant strains have caused severe damage to the global pig industry. Until now, no effective antivirals have been developed for the therapeutic treatment of PEDV infection. In the present study, we found that quercetin significantly suppressed PEDV infection...

journal_title：International journal of molecular sciences

authors： Li Z,Cao H,Cheng Y,Zhang X,Zeng W,Sun Y,Chen S,He Q,Han H

更新日期：2020-10-30 00:00:00

abstract：:The presented studies focused on the specificity binding of particular casein fractions: αS1-, β- and κ-casein (αS1CN, βCN, κCN), with zinc ions. The binding mechanism was determined by kinetic modeling using results of batch sorption. For this goal, models of zero-order kinetics, pseudo-first-order, pseudo-second-ord...

journal_title：International journal of molecular sciences

authors： Rodzik A,Pomastowski P,Railean-Plugaru V,Sprynskyy M,Buszewski B

更新日期：2020-10-30 00:00:00

abstract：:Breast cancer evolves thanks to a dense and close interaction with the surrounding tumor microenvironment (TME). Fibroblasts, leukocytes, blood and lymphatic endothelial cells and extracellular matrix are the constituents of this entity, and they synergistically play a pivotal role in all of the stages of breast cance...

journal_title：International journal of molecular sciences

authors： Zarrilli G,Businello G,Dieci MV,Paccagnella S,Carraro V,Cappellesso R,Miglietta F,Griguolo G,Guarneri V,Lo Mele M,Fassan M

更新日期：2020-10-30 00:00:00

abstract：:Plant architecture is critical for enhancing the adaptability and productivity of crop plants. Mutants with an altered plant architecture allow researchers to elucidate the genetic network and the underlying mechanisms. In this study, we characterized a novel nal1 rice mutant with short height, small panicle, and narr...

journal_title：International journal of molecular sciences

authors： Subudhi PK,Garcia RS,Coronejo S,De Leon TB

更新日期：2020-10-30 00:00:00

abstract：:Activation of the cannabinoid CB1 receptor induces different cellular signaling cascades through coupling to different effector proteins (G-proteins and β-arrestins), triggering numerous therapeutic effects. Conformational changes and rearrangements at the intracellular domain of this GPCR receptor that accompany liga...

journal_title：International journal of molecular sciences

authors： Morales P,Bruix M,Jiménez MA

更新日期：2020-10-30 00:00:00

abstract：:Tumor cells metastasize to distal organs mainly through hematogenous dissemination, where they experience considerable levels of fluid shear stress. Epithelial-mesenchymal transition (EMT) plays a critical role in tumor metastasis. However, how fluid shear stress influences the EMT phenotype of circulating tumor cells...

journal_title：International journal of molecular sciences

authors： Xin Y,Li K,Yang M,Tan Y

更新日期：2020-10-30 00:00:00

abstract：:Depressive disorders and alcohol use disorders are widespread among the general population and are significant public health and economic burdens. Alcohol use disorders often co-occur with other psychiatric conditions and this dual diagnosis is called comorbidity. Depressive disorders invariably contribute to the deve...

journal_title：International journal of molecular sciences

authors： Shor C,Zuo W,Eloy JD,Ye JH

更新日期：2020-10-30 00:00:00

abstract：:Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO-producing cells. The expression of EPO is strictly regulated by local ...

journal_title：International journal of molecular sciences

authors： Watts D,Gaete D,Rodriguez D,Hoogewijs D,Rauner M,Sormendi S,Wielockx B

更新日期：2020-10-30 00:00:00

abstract：:MicroRNAs (miRNAs) act as negative regulators of gene expression in the cytoplasm. Previous studies have identified the presence of miRNAs in the nucleus. Here we study human breast cancer-derived cell-lines (MCF-7 and MDA-MB-231) and a non-tumorigenic cell-line (MCF-10A) and compare their miRNA sequences at the splic...

journal_title：International journal of molecular sciences

authors： Mahlab-Aviv S,Zohar K,Cohen Y,Peretz AR,Eliyahu T,Linial M,Sperling R

更新日期：2020-10-30 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by fibroblasts activation, ECM accumulation, and diffused alveolar inflammation. The role of inflammation in IPF is still controversial and its involvement may follow nontraditional mechanisms. It is seen that a pathological microenvironment may af...

journal_title：International journal of molecular sciences

authors： Bonifazi M,Di Vincenzo M,Caffarini M,Mei F,Salati M,Zuccatosta L,Refai M,Mattioli-Belmonte M,Gasparini S,Orciani M

更新日期：2020-10-30 00:00:00

abstract：:The neuronal ceroid lipofuscinoses (NCLs) collectively constitute one of the most common forms of inherited childhood-onset neurodegenerative disorders. They form a heterogeneous group of incurable lysosomal storage diseases that lead to blindness, motor deterioration, epilepsy, and dementia. Traditionally the NCL dis...

journal_title：International journal of molecular sciences

authors： Shematorova EK,Shpakovski GV

更新日期：2020-10-29 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is one of the leading presentations of head and neck cancer (HNC). The first part of this review will describe the highlights of the oral microbiome in health and normal development while demonstrating how both the oral and gut microbiome can map OSCC development, progression, treat...

journal_title：International journal of molecular sciences

authors： Sami A,Elimairi I,Stanton C,Ross RP,Ryan CA

更新日期：2020-10-29 00:00:00

abstract：:Both positive and negative aspects of sport performance are currently considered. The aim of our study was to determine time- and intensity-dependent effects of a single exercise bout on redox and inflammatory status. The experiment was performed on 40 male Wistar rats subjected to treadmill running for 30 min with th...

journal_title：International journal of molecular sciences

authors： Supruniuk E,Maciejczyk M,Zalewska A,Górski J,Chabowski A

更新日期：2020-10-29 00:00:00

abstract：:We evaluated the potential of nine vitamin B3 scaffold-based derivatives as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors, as a starting point for the development of novel drugs for treating disorders with cholinergic neurotransmission-linked pathology. As the results indicate, all compounds ...

journal_title：International journal of molecular sciences

authors： Zandona A,Lihtar G,Maraković N,Miš K,Bušić V,Gašo-Sokač D,Pirkmajer S,Katalinić M

更新日期：2020-10-29 00:00:00

abstract：:Osteoporosis is a common skeletal disorder, occurring as a result of an imbalance between bone resorption and bone formation, with bone breakdown exceeding bone building. Bone resorption inhibitors, e.g., bisphosphonates, have been designed to treat osteoporosis. Teriparatide, an anabolic agent, stimulates bone format...

journal_title：International journal of molecular sciences

authors： Tang CH

更新日期：2020-10-28 00:00:00

abstract：:Humans express an expansive and detailed response to wavelength differences within the electromagnetic (EM) spectrum. This is most clearly manifest, and most studied, with respect to a relatively small range of electromagnetic radiation that includes the visible wavelengths with abutting ultraviolet and infrared, and ...

journal_title：International journal of molecular sciences

authors： Buch J,Hammond B

更新日期：2020-10-28 00:00:00

abstract：:Citral is well known for its antimicrobial, antifungal, and insecticidal activities. Natural sesquiterpene α-methylenelactones also exhibit a broad spectrum of biological activities. The aim of the study was to explore the effect of structural changes to citral molecules on citral behavior-modifying activity towards M...

journal_title：International journal of molecular sciences

authors： Dancewicz K,Szumny A,Wawrzeńczyk C,Gabryś B

更新日期：2020-10-28 00:00:00

abstract：:Dry fruits consist of two types, dehiscent and indehiscent, whereby the fruit is splitting open or remains closed at maturity, respectively. The seed, the dispersal unit (DU) of dehiscent fruits, is composed of three major parts, the embryo and the food reserve, encapsulated by the maternally-derived organ, the seed c...

journal_title：International journal of molecular sciences

authors： Grafi G

更新日期：2020-10-28 00:00:00

abstract：:Cellular communications play pivotal roles in multi-cellular species, but they do so also in uni-cellular species. Moreover, cells communicate with each other not only within the same individual, but also with cells in other individuals belonging to the same or other species. These communications occur between two uni...

journal_title：International journal of molecular sciences

authors： Combarnous Y,Nguyen TMD

更新日期：2020-10-28 00:00:00

abstract：:The insect midgut secretes a semi-permeable, acellular peritrophic membrane (PM) that maintains intestinal structure, promotes digestion, and protects the midgut from food particles and pathogenic microorganisms. Peritrophin is an important PM protein (PMP) in the PM. Here, we identified 11 peritrophins with 1-16 chit...

journal_title：International journal of molecular sciences

authors： Zha XL,Yu XB,Zhang HY,Wang H,Huang XZ,Shen YH,Lu C

更新日期：2020-10-27 00:00:00

abstract：:In allergic bronchial asthma, an increased smooth muscle contractility of the airways is one of the causes of the airway hyperresponsiveness (AHR). Increasing evidence also suggests a possible involvement of microRNAs (miRNAs) in airway diseases, including asthma, although their roles in function and pathology largely...

journal_title：International journal of molecular sciences

authors： Chiba Y,Matsumoto M,Hanazaki M,Sakai H

更新日期：2020-10-27 00:00:00

abstract：:Alterations to the programmed cell death protein-1 (PD-1) pathway were previously shown to be involved in a poorer prognosis for patients with proliferative glomerulonephritis (PGN). Here, we investigated the association between several infectious agents and the expression of PD-1 and its ligand (PD-L1) on T and B lym...

journal_title：International journal of molecular sciences

authors： Grywalska E,Smarz-Widelska I,Korona-Głowniak I,Mertowski S,Gosik K,Hymos A,Ludian J,Niedźwiedzka-Rystwej P,Roliński J,Załuska W

更新日期：2020-10-27 00:00:00

abstract：:Clinical conditions leading to chronic pain show important sex-related differences in the prevalence, severity, and degree of functional disability. Decades of epidemiological and clinical studies have demonstrated that women are more sensitive to pain than men. Arthritis, including rheumatoid arthritis (RA) and osteo...

journal_title：International journal of molecular sciences

authors： Kim JR,Kim HA

更新日期：2020-10-26 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic, inflammatory, and systemic autoimmune disease that affects the connective tissue and primarily the joints. If not treated, RA ultimately leads to progressive cartilage and bone degeneration. The etiology of the pathogenesis of RA is unknown, demonstrating heterogeneity in its cl...

journal_title：International journal of molecular sciences

authors： Damerau A,Gaber T

更新日期：2020-10-25 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) is an attractive target for treating patients with B cell malignancies and autoimmune diseases. Many BTK inhibitors have been identified; however, like other kinase inhibitors, they lack diversity in their core structures. Therefore, it is important to secure a novel scaffold that occupi...

journal_title：International journal of molecular sciences

authors： Cho H,Lee E,Kwon HA,Seul L,Jeon HJ,Yu JH,Ryu JH,Jeon R

更新日期：2020-10-25 00:00:00

abstract：:Sarcopenia is a condition of muscle dysfunction, commonly associated with chronic liver disease (CLD), characterized by a decline in muscle strength, the activation of the ubiquitin-proteasome system (UPS), and oxidative stress. We recently described a murine model of CLD-induced sarcopenia by intake of hepatotoxin 3,...

journal_title：International journal of molecular sciences

authors： Abrigo J,Campos F,Gonzalez F,Aguirre F,Gonzalez A,Huerta-Salgado C,Conejeros S,Simon F,Arrese M,Cabrera D,Elorza AA,Cabello-Verrugio C

更新日期：2020-10-25 00:00:00

abstract：:Iron is an essential mineral participating in different functions of the organism under physiological conditions. Numerous biological processes, such as oxygen and lipid metabolism, protein production, cellular respiration, and DNA synthesis, require the presence of iron, and mitochondria play an important role in the...

journal_title：International journal of molecular sciences

authors： Ravingerová T,Kindernay L,Barteková M,Ferko M,Adameová A,Zohdi V,Bernátová I,Ferenczyová K,Lazou A

更新日期：2020-10-24 00:00:00

abstract：:The synthesis of Mobil Composition of Matter 41 (MCM-41) mesoporous silica nanoparticles (MSNs) of controlled sizes and porous structure has been performed at laboratory and pilot plant scales. Firstly, the effects of the main operating conditions (TEOS -Tetraethyl ortosilicate- addition rate, nanoparticle maturation ...

journal_title：International journal of molecular sciences

authors： Castillo RR,de la Torre L,García-Ochoa F,Ladero M,Vallet-Regí M

更新日期：2020-10-24 00:00:00

abstract：:Multiple myeloma (MM)-induced bone disease occurs through hyperactivation of osteoclasts by several factors secreted by MM cells. MM cell-secreted factors induce osteoclast differentiation and activation via direct and indirect actions including enhanced expression of receptor activator of nuclear factor κB ligand (RA...

journal_title：International journal of molecular sciences

authors： Tsubaki M,Seki S,Takeda T,Chihara A,Arai Y,Morii Y,Imano M,Satou T,Shimomura K,Nishida S

更新日期：2020-10-24 00:00:00

abstract：:Dietary supplementation with polyunsaturated fatty acids (PUFA) n-3 can affect cutaneous wound healing; however, recent findings demonstrate the variable extent of their influence on the quality of healing. Here, we compare the effect of several dietary oils, containing different levels of PUFA n-3 and PUFA n-6, on wo...

journal_title：International journal of molecular sciences

authors： Komprda T,Sladek Z,Sevcikova Z,Svehlova V,Wijacki J,Guran R,Do T,Lackova Z,Polanska H,Vrlikova L,Popelkova V,Michalek P,Zitka O,Buchtova M

更新日期：2020-10-24 00:00:00

abstract：:Understanding the importance of oral microbiota in human health and disease also leads to an expansion of the knowledge on functional, metabolic, and molecular alterations directly contributing to oral and systemic pathologies. To date, a compelling number of studies have documented the crucial role of some oral cavit...

journal_title：International journal of molecular sciences

authors： Suprewicz Ł,Tokajuk G,Cieśluk M,Deptuła P,Sierpińska T,Wolak P,Wollny T,Tokajuk J,Głuszek S,Piktel E,Bucki R

更新日期：2020-10-24 00:00:00

abstract：:Merging targeted systemic gene delivery and systemic chemotherapy against cancer, chemovirotherapy, has the potential to improve chemotherapy and gene therapy treatments and overcome cancer resistance. We introduced a bacteriophage (phage) vector, named human adeno-associated virus (AAV)/phage or AAVP, for the systemi...

journal_title：International journal of molecular sciences

authors： Tsafa E,Bentayebi K,Topanurak S,Yata T,Przystal J,Fongmoon D,Hajji N,Waramit S,Suwan K,Hajitou A

更新日期：2020-10-23 00:00:00

abstract：:Plant-extracted triterpenoids belong to a class of bioactive compounds with pleotropic functions, including antioxidant, anti-cancer, and anti-inflammatory effects. In this work, we investigated the anti-inflammatory and anti-oxidative activities of a semisynthetic derivative of 18βH-glycyrrhetinic acid (18βH-GA), sol...

journal_title：International journal of molecular sciences

authors： Markov AV,Sen'kova AV,Babich VO,Odarenko KV,Talyshev VA,Salomatina OV,Salakhutdinov NF,Zenkova MA,Logashenko EB

更新日期：2020-10-23 00:00:00

abstract：:Members of neuropeptide B/W signaling system have been predominantly detected and mapped within the CNS. In the rat, this system includes neuropeptide B (NPB), neuropeptide W (NPW) and their specific receptor NPBWR1. This signaling system has a wide spectrum of functions including a role in modulation of inflammatory ...

journal_title：International journal of molecular sciences

authors： Pandey S,Tuma Z,Peroni E,Monasson O,Papini AM,Chottova Dvorakova M

更新日期：2020-10-22 00:00:00

abstract：:Neonatal seizures are one of the most common comorbidities of neonatal encephalopathy, with seizures aggravating acute injury and clinical outcomes. Current treatment can control early life seizures; however, a high level of pharmacoresistance remains among infants, with increasing evidence suggesting current anti-sei...

journal_title：International journal of molecular sciences

authors： Menéndez Méndez A,Smith J,Engel T

更新日期：2020-10-22 00:00:00

abstract：:Nosocomial (hospital-acquired) infections remain a serious challenge for health systems. The reason for this lies not only in the local imperfection of medical practices and protocols. The frequency of infection with antibiotic-resistant strains of bacteria is growing every year, both in developed and developing count...

journal_title：International journal of molecular sciences

authors： Slizen MV,Galzitskaya OV

更新日期：2020-10-22 00:00:00

abstract：:While necroptosis has been shown to contribute to the pathogenesis of post-infarction heart failure (HF), the role of autophagy remains unclear. Likewise, linkage between these two cell death modalities has not been sufficiently investigated. HF was induced by 60-min left coronary occlusion in adult Wistar rats and he...

journal_title：International journal of molecular sciences

authors： Lichý M,Szobi A,Hrdlička J,Neckář J,Kolář F,Adameová A

更新日期：2020-10-21 00:00:00